RESOURCES

Tools for discovery. Resources for science.

We share data, research tools, and experimental knowledge to help turn biological questions into reproducible discoveries.

Transgenic & knock-in mouse models

Sequencing & analysis tools

  • Sample enrichment for single-nucleus sequencing using concanavalin A-conjugated magnetic beads

Note: mice shown in gray are not currently available in the lab. Please contact us for additional information.

STAR Protoc. 2023;4(4):102595. PubMed PMID: 37740915. PDF

Explore the genomic datasets underlying our published research.

  • Comparative transcriptomic analyses of developing POMC and NPY/AgRP neurons in E15.5 mouse embryos

J Neurosci. 2020;40(16). PubMed PMID: 32213554. PDF

  • Hypothalamic gene expression signature associated with chronic risperidone treatment in C57BL/6 mice

J Exp Med. 2021;218(7). PubMed PMID: 33978701. PDF

  • Single-nucleus RNA-seq analysis of adult AgRP-Cre neurons in the arcuate nucleus of C57BL/6 mice

J Exp Med. 2022;219(8). PubMed PMID: 35796804. PDF

  • Bulk RNA-seq analysis of hypothalamic MC4R-Cre neurons in adult C57BL/6 mice

Sci Transl Med. 2025;17(781). PubMed PMID:39813316. PDF

  • Single-nucleus RNA-seq analysis of Sim1-Cre neurons in the paraventricular nucleus of the hypothalamus

Sci Transl Med. 2025;17(781). PubMed PMID:39813316. PDF

  • Single-nuclei multiome analyses of POMC-derived neurons in the adult mouse mediobasal hypothalamus

Neuron 2026;114(1210). PubMed PMID: 41702397 PDF

Open-source diets for modeling antipsychotic drug–induced metabolic syndrome in female mice

  • A rodent diet for modeling olanzapine-induced metabolic syndrome

J Clin Invest. 2017;127(9). PubMed PMID: 28805659. PDF

  • A rodent diet for modeling risperidone-induced metabolic syndrome

J Exp Med. 2021;218(7). PubMed PMID: 33978701. PDF

  • A rodent diet for modeling clozapine-induced metabolic syndrome

bioRxiv. 2024.06.07.597973. PDF

All reported diets are fully open source and can be purchased directly from Research Diets.

Public datasets

Protocols, code, and workflows for single-cell and multiomic studies.

JOIN THE LIU LAB

Bring your curiosity. Build your independence.

We welcome inquiries from UTSW graduate students interested in research rotations and from postdoctoral researchers who want to connect neuroscience, genetics, metabolism, and medicine. Trainees receive rigorous scientific guidance, increasing intellectual ownership, and active support for communication, funding, and career development.

Center for Hypothalamic Research

Departments of Internal Medicine and Neuroscience

UT Southwestern Medical Center, Dallas, Texas, USA

Chen Liu Lab

Neural control of homeostasis