2024

Li L, Hernandez CC, Gimenrez LE, Xu B, Dahir NS, Swati, Birnbaum SG, Cone RD, Liu C. Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia. bioRxiv. 2024.06.07.597981 2019:753434. PDF

2023

Zhao S, Lin Q, Xiong W, Li L, Straub L, Zhang D, Zapata R, Zhu Q, Sun XN, Zhang Z, Funcke JB, Li C, Chen S, Zhu Y, Jiang N, Li G, Xu Z, Wyler SC, Wang MY, Bai J, Han X, Kusminski CM, Zhang N, An Z, Elmquist JK, Osborn O, Liu C, Scherer PE. Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders. Sci Transl Med. 2023;15(723). PubMed PMID: 37992151.

Zapata RC, Zhang D, Libster A, Porcu A, Montilla-Perez P, Nur A, Xu B, Zhang Z, Correa SM, Liu C, Telese F, Osborn O. Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia. Mol Psychiatry. 2023. PubMed PMID: 36765131.

Wickramasinghe PB, Qian S, Langley LE, Liu C, Jia L. Hepatocyte Toll-Like Receptor 4 Mediates Alcohol-Induced Insulin Resistance in Mice. Biomolecules. 2023;13(3). PubMed PMID: 36979389.

Semple EA, Harberson MT, Xu B, Rashleigh R, Cartwright TL, Braun JJ, Custer AC, Liu C, Hill JW. Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice. Front Endocrinol (Lausanne). 2023. PubMed PMID: 37033219.

Li L*, Xu B, Liu C*. Sample enrichment for single-nucleus sequencing using concanavalin A-conjugated magnetic beads. STAR Protoc. 2023;4(4):102595. PubMed PMID: 37740915. PDF

2022

Li L, Wyler SC, Leon-Mercado LA, Xu B, Oh Y, Swati, Chen X, Wan R, Arnold AG, Jia L, Wang G, Nautiyal K, Hen R, Sohn JW*, Liu C*. Delineating a serotonin 1B receptor circuit for appetite suppression in mice. J Exp Med. 2022;219(8). PubMed PMID: 35796804. PDF

2021

Yoo ES, Li L, Jia L, Lord CC, Lee CE, Birnbaum SG, Vianna CR, Berglund ED, Cunningham KA, Xu Y, Sohn JW*, Liu C*. Galphai/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Cell Rep. 2021;37(7). PubMed PMID: 34788630. PDF

Shankar K, Metzger NP, Singh O, Mani BK, Osborne-Lawrence S, Varshney S, Gupta D, Ogden SB, Takemi S, Richard CP, Nandy K, Liu C, Zigman JM. LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Mol Metab. 2021:101327. PubMed PMID: 34428557.

Li L, Yoo ES, Li X, Wyler SC, Chen X, Wan R, Arnold AG, Birnbaum SG, Jia L, Sohn JW*, Liu C*. The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain. J Exp Med. 2021;218(7). PubMed PMID: 33978701. PDF

Landy MA, Goyal M, Casey KM, Liu C, Lai HC. Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation. Cell Rep. 2021;34(13):108913. PubMed PMID: 33789102.

Castorena CM, Caron A, Michael NJ, Ahmed NI, Arnold AG, Lee J, Lee CE, Limboy C, Tinajero AS, Granier M, Wang S, Horton JD, Holland WL, Lee S, Liu C, Fujikawa T, Elmquist JK. CB1Rs in VMH Neurons Regulate Glucose Homeostasis but not Body Weight. Am J Physiol Endocrinol Metab. 2021. PubMed PMID: 34097543.

2020

Shankar K, Gupta D, Mani BK, Findley BG, Osborne-Lawrence S, Metzger NP, Liu C, Berglund ED, Zigman JM. Ghrelin Protects Against Insulin-Induced Hypoglycemia in a Mouse Model of Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2020;11:606. PubMed PMID: 33042003.

Park S, Williams KW, Liu C*, Sohn JW*. A neural basis for tonic suppression of sodium appetite. Nat Neurosci. 2020;23(3). PubMed PMID: 31959933. PDF

Landy MA, Goyal M, Casey KM, Liu C, Lai HC. Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation. bioRxiv. 2020:2020.09.07.286286. doi: 10.1101/2020.09.07.286286.

Chen X, Wyler SC, Li L, Arnold AG, Wan R, Jia L, Landy MA, Lai HC, Xu P, Liu C*. Comparative Transcriptomic Analyses of Developing Melanocortin Neurons Reveal New Regulators for the Anorexigenic Neuron Identity. J Neurosci. 2020;40(16):3165-77. PubMed PMID: 32213554. PDF

2019

Shankar K, Gupta D, Mani BK, Findley BG, Lord CC, Osborne-Lawrence S, Metzger NP, Pietra C, Liu C, Berglund ED, Zigman JM. Acyl-ghrelin is Permissive for the Normal Counterregulatory Response to Insulin-induced Hypoglycemia. Diabetes. 2019. PubMed PMID: 31685528.

Chen X, Wyler SC, Li L, Arnold AG, Wan R, Xu P, Liu C*. Transcriptomic Profiling of Developing Melanocortin Neurons Reveals a Role for Prdm12 in Energy Balance. bioRxiv. 2019:753434. doi: 10.1101/753434.

2018

Rodriguez JA, Bruggeman EC, Mani BK, Osborne-Lawrence S, Lord CC, Roseman HF, Viroslav HL, Vijayaraghavan P, Metzger NP, Gupta D, Shankar K, Pietra C, Liu C, Zigman JM. Ghrelin Receptor Agonist Rescues Excess Neonatal Mortality in a Prader-Willi Syndrome Mouse Model. Endocrinology. PubMed PMID: 30380028.

Jia L, Chang X, Qian S, Liu C, Lord CC, Ahmed N, Lee CE, Lee S, Gautron L, Mitchell MC, Horton JD, Scherer PE, Elmquist JK. Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease. Mol Metab. 2018;14:121-9. PubMed PMID: 29884546.

Caron A, Dungan Lemko HM, Castorena CM, Fujikawa T, Lee S, Lord CC, Ahmed N, Lee CE, Holland WL, Liu C, Elmquist JK. POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels. Elife. 2018;7. PubMed PMID: 29528284.

2017

Wyler SC, Lord CC, Lee S, Elmquist JK, Liu C*. Serotonergic Control of Metabolic Homeostasis. Front Cell Neurosci. 2017. PubMed PMID: 28979187. PDF

Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metab. 2017;25(3):647-60. PubMed PMID: 28190775.

Lord CC, Wyler SC, Wan R, Castorena CM, Ahmed N, Mathew D, Lee S, Liu C*, Elmquist JK*. The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C. J Clin Invest. 2017;127(9):3402-6. PubMed PMID: 28805659. PDF

2016

He Y, Shu G, Yang Y, Xu P, Xia Y, Wang C, Saito K, Hinton A, Jr., Yan X, Liu C, Wu Q, Tong Q, Xu Y. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Cell Rep. 2016;17(7):1807-18. PubMed PMID: 27829152.

2015 and Prior

Wang Q*, Liu C*, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM. Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin. Mol Metab. 2014;3(1):64-72. PubMed PMID: 24567905.

Liu C, Lee S, Elmquist JK. Circuits controlling energy balance and mood: inherently intertwined or just complicated intersections? Cell Metab. 2014;19(6):902-9. PubMed PMID: 24630814.

Liu C*, Bookout AL*, Lee S, Sun K, Jia L, Lee C, Udit S, Deng Y, Scherer PE, Mangelsdorf DJ, Gautron L, Elmquist JK. PPARgamma in vagal neurons regulates high-fat diet induced thermogenesis. Cell Metab. 2014;19(4):722-30. PubMed PMID: 24703703.

Jia L, Vianna CR, Fukuda M, Berglund ED, Liu C, Tao C, Sun K, Liu T, Harper MJ, Lee CE, Lee S, Scherer PE, Elmquist JK. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance. Nat Commun. 2014;5:3878. PubMed PMID: 24815961.

Jackson AC, Liu C, Fukuda M, Lazarus M, Gautron L. Neuroanatomy and transgenic technologies. Front Neuroanat. 2014;8:157. PubMed PMID: 25653595.

Chen Z, Holland W, Shelton JM, Ali A, Zhan X, Won S, Tomisato W, Liu C, Li X, Moresco EM, Beutler B. Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling. Proc Natl Acad Sci U S A. 2014;111(20):7367-72. PubMed PMID: 24799716.

Berglund ED*, Liu C*, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J Clin Invest. 2013;123(12):5061-70. PubMed PMID: 24177424.

Liu C, Elmquist JK. Tipping the scales early: probing the long-term effects of obesity. J Clin Invest. 2012;122(11):3840-2. PubMed PMID: 23093788.

Liu C, Deneris ES. Transcriptional control of serotonin-modulated behavior and physiology. Neuropsychopharmacology. 2011;36(1):361-2. PubMed PMID: 21116255.

Oh E, Maejima T, Liu C, Deneris E, Herlitze S. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. J Biol Chem. 2010;285(40):30825-36. PubMed PMID: 20643652.

Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES. Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci. 2010;13(10):1190-8. PubMed PMID: 20818386.